Fatty acid synthesis in obese insulin resistant diabetic mice
RA Memon, C Grunfeld, AH Moser… - Hormone and …, 1994 - thieme-connect.com
RA Memon, C Grunfeld, AH Moser, KR Feingold
Hormone and metabolic research, 1994•thieme-connect.comDiabetes is associated with hypertriglyceridemia and it has been suggested that the
intestine contributes to this elevation. Recent studies have shown that in animals with IDDM,
fatty acid (FA) synthesis is decreased in the liver and increased in the small intestine (SI).
The purpose of the present study was to measure FA synthesis in the liver and SI of animals
with NIDDM. In both db/db and ob/ob animals the incorporation of 3 H 2 O into FA was
increased in the SI (10 fold in db/db and 2.2 fold in ob/ob). FA synthesis was also increased …
intestine contributes to this elevation. Recent studies have shown that in animals with IDDM,
fatty acid (FA) synthesis is decreased in the liver and increased in the small intestine (SI).
The purpose of the present study was to measure FA synthesis in the liver and SI of animals
with NIDDM. In both db/db and ob/ob animals the incorporation of 3 H 2 O into FA was
increased in the SI (10 fold in db/db and 2.2 fold in ob/ob). FA synthesis was also increased …
Summary
Diabetes is associated with hypertriglyceridemia and it has been suggested that the intestine contributes to this elevation. Recent studies have shown that in animals with IDDM, fatty acid (FA) synthesis is decreased in the liver and increased in the small intestine (SI). The purpose of the present study was to measure FA synthesis in the liver and SI of animals with NIDDM. In both db/db and ob/ob animals the incorporation of 3 H 2 O into FA was increased in the SI (10 fold in db/db and 2.2 fold in ob/ob). FA synthesis was also increased in the liver of NIDDM (9 fold in db/db and 6 fold in ob/ob). These results provide further evidence that diabetes leads to changes in lipid metabolism in the SI.
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