[HTML][HTML] Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic …
Previous studies have shown that the rate of fatty acid synthesis is elevated by more than 20-
fold in livers of transgenic mice that express truncated nuclear forms of sterol regulatory
element-binding proteins (SREBPs). This was explained in part by an increase in the levels
of mRNA for the two major enzymes of fatty acid synthesis, acetyl-CoA carboxylase and fatty
acid synthase, whose transcription is stimulated by SREBPs. Fatty acid synthesis also
requires a source of acetyl-CoA and NADPH. In the current studies we show that the levels …
fold in livers of transgenic mice that express truncated nuclear forms of sterol regulatory
element-binding proteins (SREBPs). This was explained in part by an increase in the levels
of mRNA for the two major enzymes of fatty acid synthesis, acetyl-CoA carboxylase and fatty
acid synthase, whose transcription is stimulated by SREBPs. Fatty acid synthesis also
requires a source of acetyl-CoA and NADPH. In the current studies we show that the levels …