Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity
SL Chamlin, J Kao, IJ Frieden, MY Sheu… - Journal of the American …, 2002 - Elsevier
Background: It is currently fashionable to consider atopic dermatitis (AD), like other
inflammatory dermatoses, as immunologic in pathogenesis (“inside-outside” hypothesis).
Accordingly, topical glucocorticoids and other immunosuppressive agents are mainstays of
therapy, but the risk of toxicity from these agents is not insignificant, particularly in children.
Alternatively, because stratum corneum (SC) permeability barrier function is also abnormal
in AD, it has been hypothesized that the barrier abnormality could drive disease activity. Yet …
inflammatory dermatoses, as immunologic in pathogenesis (“inside-outside” hypothesis).
Accordingly, topical glucocorticoids and other immunosuppressive agents are mainstays of
therapy, but the risk of toxicity from these agents is not insignificant, particularly in children.
Alternatively, because stratum corneum (SC) permeability barrier function is also abnormal
in AD, it has been hypothesized that the barrier abnormality could drive disease activity. Yet …