Steroid hormone receptors and Stat factors comprise two distinct families of inducible
transcription factors. Activation of a member of each family, namely the glucocorticoid
receptor by glucocorticoids and Stat5 by prolactin, is required for the efficient induction of the
expression of milk protein genes in the mammary epithelium. We have studied the mode of
interaction between Stat5 and the glucocorticoid receptor in the activation of β-casein gene
transcription. The functional role of potential half-palindromic glucocorticoid receptor-binding …