Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: multifactorial states of clinical importance
T Kino, GP Chrousos - Journal of allergy and clinical immunology, 2002 - jacionline.org
APRIL 2002 cells by means of incubation with IL-2 and IL-4 combined or IL-13 alone. These
changes include decreases in the affinity of the nuclear fraction of the GR for its ligand and
resistance of the cells to glucocorticoids in vitro. 13, 14 Irusen et al8 suggest that the p38
mitogen-activated protein kinase (MAPK), stimulated by simultaneous administration of IL-2
and IL-4, might cause reduction in the affinity of the GR to its ligand through direct
phosphorylation of the GR at serine 226 (Fig 1, C). Several other protein kinases involved in …
changes include decreases in the affinity of the nuclear fraction of the GR for its ligand and
resistance of the cells to glucocorticoids in vitro. 13, 14 Irusen et al8 suggest that the p38
mitogen-activated protein kinase (MAPK), stimulated by simultaneous administration of IL-2
and IL-4, might cause reduction in the affinity of the GR to its ligand through direct
phosphorylation of the GR at serine 226 (Fig 1, C). Several other protein kinases involved in …
