p38 Mitogen-activated protein kinase–induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma
Background: Although glucocorticoids are the most effective treatment for chronic
inflammatory diseases, such as asthma, some patients show a poor response. IL-2
combined with IL-4 can alter glucocorticoid receptor (GR) ligand-binding affinity and
modulate glucocorticoid function. Objective: We sought to confirm the altered ligand-binding
affinity in a distinct group of steroid-dependent asthmatic subjects and examine the
mechanism by which IL-2 and IL-4 modify the ligand-binding affinity of the GR. Methods: We …
inflammatory diseases, such as asthma, some patients show a poor response. IL-2
combined with IL-4 can alter glucocorticoid receptor (GR) ligand-binding affinity and
modulate glucocorticoid function. Objective: We sought to confirm the altered ligand-binding
affinity in a distinct group of steroid-dependent asthmatic subjects and examine the
mechanism by which IL-2 and IL-4 modify the ligand-binding affinity of the GR. Methods: We …
