IL-2-lnduced Cellular Events
J Gomez, A Gonzalez, C Martinez-A… - Critical Reviews™ in …, 1998 - dl.begellhouse.com
J Gomez, A Gonzalez, C Martinez-A, A Rebollo
Critical Reviews™ in Immunology, 1998•dl.begellhouse.comIn this review we discuss several molecules that are attractive candidates as transducing
molecules involved in signaling processes. IL-2 receptor signaling is a complex process
involving a large number of molecules: Ras, Rho, PI3 kinase, PKC, Akt, transcription factors
NF-AT, and NF-kB and some target genes such as bcl-2, c-myc, c-jun and c-fos. Ras and
Rho have been defined as dual molecules because Ras-and Rho-initiated signals can
either promote or inhibit apoptosis.
molecules involved in signaling processes. IL-2 receptor signaling is a complex process
involving a large number of molecules: Ras, Rho, PI3 kinase, PKC, Akt, transcription factors
NF-AT, and NF-kB and some target genes such as bcl-2, c-myc, c-jun and c-fos. Ras and
Rho have been defined as dual molecules because Ras-and Rho-initiated signals can
either promote or inhibit apoptosis.
Abstract
In this review we discuss several molecules that are attractive candidates as transducing molecules involved in signaling processes. IL-2 receptor signaling is a complex process involving a large number of molecules: Ras, Rho, PI3 kinase, PKC, Akt, transcription factors NF-AT, and NF-kB and some target genes such as bcl-2, c-myc, c-jun and c-fos. Ras and Rho have been defined as dual molecules because Ras-and Rho-initiated signals can either promote or inhibit apoptosis.
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