Immunosuppression by glucocorticoids: inhibition of production of multiple lymphokines by in vivo administration of dexamethasone
JE Kunicka, MA Talle, GH Denhardt, M Brown… - Cellular …, 1993 - Elsevier
Glucocorticoids are extremely potent immunosuppressive agents, capable of directly
affecting the function of lymphocytes. We studied the effect of in vivo dexamethasone (DEX)
administration on anti-CD3-induced lymphocyte proliferation and lymphokine production in
mice. To characterize the kinetics and dose responsiveness of lymphocytes to DEX,
splenocytes from BALB/c mice that had received a single dose of DEX in vivo were cultured
in vitro with suboptimal and optimal concentrations of anti-CD3 monoclonal antibody. Cell …
affecting the function of lymphocytes. We studied the effect of in vivo dexamethasone (DEX)
administration on anti-CD3-induced lymphocyte proliferation and lymphokine production in
mice. To characterize the kinetics and dose responsiveness of lymphocytes to DEX,
splenocytes from BALB/c mice that had received a single dose of DEX in vivo were cultured
in vitro with suboptimal and optimal concentrations of anti-CD3 monoclonal antibody. Cell …
