[HTML][HTML] Apolipoprotein E inhibits serum-stimulated cell proliferation and enhances serum-independent cell proliferation
YY Ho, RJ Deckelbaum, Y Chen, T Vogel… - Journal of Biological …, 2001 - ASBMB
Independently of its role in lipid homeostasis, apolipoprotein E (apoE) inhibits cell
proliferation. We compared the effects of apoE added to media (exogenous apoE) with the
effects of stably expressed apoE (endogenous apoE) on cell proliferation. Exogenous and
endogenous apoE increased population doubling times by 30–50% over a period of 14
days by prolonging the G 1 phase of the cell cycle. Exogenous and endogenous apoE also
decreased serum-stimulated DNA synthesis by 30–50%. However, apoE did not cause cell …
proliferation. We compared the effects of apoE added to media (exogenous apoE) with the
effects of stably expressed apoE (endogenous apoE) on cell proliferation. Exogenous and
endogenous apoE increased population doubling times by 30–50% over a period of 14
days by prolonging the G 1 phase of the cell cycle. Exogenous and endogenous apoE also
decreased serum-stimulated DNA synthesis by 30–50%. However, apoE did not cause cell …
