Hyaluronate levels and markers of oxidative stress in the serum of Sudanese subjects at risk of infection with Schistosoma mansoni

M Pascal, OMS Abdallahi, NEMA Elwali… - Transactions of the …, 2000 - Elsevier
We showed previously that infection by Schistosoma mansoni not only triggers the
production of reactive oxygen species in mouse liver but also leads to the alteration of
antioxidant defences. To determine whether such events occur in humans, we measured the
serum markers of oxidative stress, ie, lipid peroxides and protein carbonyl, as well as
hyaluronate levels in subjects in the Managil area of the Sudan. Grades of fibrosis were
determined by ultrasonographic examination. Two groups were used as controls, one …