Development of eosinophil peroxidase activity and concomitant alteration of the antioxidant defenses in the liver of mice infected with Schistosoma mansoni
B Gharib, OMS Abdallahi, H Dessein, M De Reggi - Journal of Hepatology, 1999 - Elsevier
Background/Aims: The tropical parasite Schistosoma mansoni causes granulomatous
inflammation following lodging of eggs in portal capillaries. In vitro studies indicated that the
host reaction should involve reactive oxygen intermediates; however, it is not known what
occurs in vivo at the site of the disease. Moreover, the ultimate pathophysiological effects of
oxidative processes depend upon antioxidant factors, which are investigated in this study.
Methods: We explored the changes in the major enzyme activities involved in liver redox …
inflammation following lodging of eggs in portal capillaries. In vitro studies indicated that the
host reaction should involve reactive oxygen intermediates; however, it is not known what
occurs in vivo at the site of the disease. Moreover, the ultimate pathophysiological effects of
oxidative processes depend upon antioxidant factors, which are investigated in this study.
Methods: We explored the changes in the major enzyme activities involved in liver redox …
