Ras redux: rethinking how and where Ras acts
SR Hingorani, DA Tuveson - Current opinion in genetics & development, 2003 - Elsevier
SR Hingorani, DA Tuveson
Current opinion in genetics & development, 2003•ElsevierRas proteins couple surface receptor stimulation to an ever-expanding array of effector
pathways. The integrated activities of these signaling pathways result in a range of
biological responses depending on cellular context and conditions. Decoding the various
inputs that underlie Ras-induced proliferation and transformation, in particular, holds the
promise of more effective cancer therapies. Recent findings have provided new and
unexpected insights into the predominant pathways Ras employs to transform human cells …
pathways. The integrated activities of these signaling pathways result in a range of
biological responses depending on cellular context and conditions. Decoding the various
inputs that underlie Ras-induced proliferation and transformation, in particular, holds the
promise of more effective cancer therapies. Recent findings have provided new and
unexpected insights into the predominant pathways Ras employs to transform human cells …
Ras proteins couple surface receptor stimulation to an ever-expanding array of effector pathways. The integrated activities of these signaling pathways result in a range of biological responses depending on cellular context and conditions. Decoding the various inputs that underlie Ras-induced proliferation and transformation, in particular, holds the promise of more effective cancer therapies. Recent findings have provided new and unexpected insights into the predominant pathways Ras employs to transform human cells and the subcellular platforms from which it can act.
Elsevier
