The trials and tribulations of IL-5, eosinophils, and allergic asthma
PM O'Byrne, MD Inman, K Parameswaran - Journal of allergy and clinical …, 2001 - Elsevier
Eosinophils have been suggested to be part of the pathologic process that characterizes
asthma, and their recruitment into the upper or lower airways appears to be essential for the
clinical manifestations of allergen inhalation. IL-5 is a cytokine necessary for the
development, differentiation, recruitment, activation, and survival of eosinophils. Allergen
inhalation increases the production of IL-5 in the airways as measured in bronchoalveolar
lavage cells and induced sputum. The relationship between IL-5 and the development of …
asthma, and their recruitment into the upper or lower airways appears to be essential for the
clinical manifestations of allergen inhalation. IL-5 is a cytokine necessary for the
development, differentiation, recruitment, activation, and survival of eosinophils. Allergen
inhalation increases the production of IL-5 in the airways as measured in bronchoalveolar
lavage cells and induced sputum. The relationship between IL-5 and the development of …