An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia
K Mackay, D Mochly-Rosen - Journal of Biological Chemistry, 1999 - ASBMB
Cellular ischemia results in activation of a number of kinases, including p38 mitogen-
activated protein kinase (MAPK); however, it is not yet clear whether p38 MAPK activation
plays a role in cellular damage or is part of a protective response against ischemia. We have
developed a model to study ischemia in cultured neonatal rat cardiac myocytes. In this
model, two distinct phases of p38 MAPK activation were observed during ischemia. The first
phase began within 10 min and lasted less than 1 h, and the second began after 2 h and …
activated protein kinase (MAPK); however, it is not yet clear whether p38 MAPK activation
plays a role in cellular damage or is part of a protective response against ischemia. We have
developed a model to study ischemia in cultured neonatal rat cardiac myocytes. In this
model, two distinct phases of p38 MAPK activation were observed during ischemia. The first
phase began within 10 min and lasted less than 1 h, and the second began after 2 h and …
