Although very low density lipoprotein (VLDL) receptor (VLDLr) knockout mice have been
reported to have no lipoprotein abnormalities, they develop less adipose tissue than control
mice when fed a high calorie diet. Mice that are deficient in adipose tissue expression of
lipoprotein lipase (LpL) also have less fat, but only when crossed with ob/ob mice. We
hypothesized that the VLDLr, a protein that will bind and transport LpL, is required for
optimal LpL actions in vivo and that hypertriglyceridemia due to VLDLr deficiency is …