Thyroid hormone differentially affects mRNA levels of Ca-ATPase isozymes of sarcoplasmic reticulum in fast and slow skeletal muscle
WS Simonides, GC van der Linden, C van Hardeveld - FEBS letters, 1990 - Elsevier
WS Simonides, GC van der Linden, C van Hardeveld
FEBS letters, 1990•ElsevierAbstract mRNA levels for the type I and type II isoforms of sarcoplasmic reticulum (SR) Ca-
ATPase were determined in soleus (SOL) and extensor digitorum longus (EDL) muscle of
euthyroid (normal), hypothyroid, and hyperthyroid rats. Total Ca-ATPase mRNA content of
hyperthyroid muscle was 1.5-fold (EDL) and 6-fold (SOL) higher compared to hypothyroid
muscle, with corresponding increases in total SR Ca-ATPase activity. EDL contained only
type II Ca-ATPase mRNA. In SOL type I mRNA was the major form in hypothyroidism (98%) …
ATPase were determined in soleus (SOL) and extensor digitorum longus (EDL) muscle of
euthyroid (normal), hypothyroid, and hyperthyroid rats. Total Ca-ATPase mRNA content of
hyperthyroid muscle was 1.5-fold (EDL) and 6-fold (SOL) higher compared to hypothyroid
muscle, with corresponding increases in total SR Ca-ATPase activity. EDL contained only
type II Ca-ATPase mRNA. In SOL type I mRNA was the major form in hypothyroidism (98%) …
Abstract
mRNA levels for the type I and type II isoforms of sarcoplasmic reticulum (SR) Ca-ATPase were determined in soleus (SOL) and extensor digitorum longus (EDL) muscle of euthyroid (normal), hypothyroid, and hyperthyroid rats. Total Ca-ATPase mRNA content of hyperthyroid muscle was 1.5-fold (EDL) and 6-fold (SOL) higher compared to hypothyroid muscle, with corresponding increases in total SR Ca-ATPase activity. EDL contained only type II Ca-ATPase mRNA. In SOL type I mRNA was the major form in hypothyroidism (98%), but the type II mRNA content was stimulated 150-fold by T3, accounting for 50% of the Ca-ATPase mRNA in hyperthyroidism.
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