[HTML][HTML] Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice
WE Hofmann, X Liu, CM Bearden, ME Harper… - Journal of Biological …, 2001 - ASBMB
An interaction between free fatty acids and UCP1 (uncoupling protein-1) leading to de-
energization of mitochondria was assumed to be a key event for triggering heat production
in brown fat. Recently, Matthiaset al., finding indistinguishable de-energization of isolated
brown fat mitochondria by fatty acids in UCP1-deficient mice and control mice, challenged
this assumption (Matthias, A., Jacobsson, A., Cannon, B., and Nedergaard, J.(1999) J. Biol.
Chem. 274, 28150–28160). Since their results were obtained using UCP1-deficient and …
energization of mitochondria was assumed to be a key event for triggering heat production
in brown fat. Recently, Matthiaset al., finding indistinguishable de-energization of isolated
brown fat mitochondria by fatty acids in UCP1-deficient mice and control mice, challenged
this assumption (Matthias, A., Jacobsson, A., Cannon, B., and Nedergaard, J.(1999) J. Biol.
Chem. 274, 28150–28160). Since their results were obtained using UCP1-deficient and …