[HTML][HTML] Tumor necrosis factor-α-converting enzyme mediates the inducible cleavage of fractalkine
CL Tsou, CA Haskell, IF Charo - Journal of Biological Chemistry, 2001 - ASBMB
Fractalkine (FK, CX3CL1) is a novel multidomain protein expressed on the surface of
endothelial cells. As a full-length transmembrane protein, FK binds cells expressing
CX3CR1, its cognate receptor, with high affinity. Proteolytic cleavage of FK releases a
soluble form that is a potent chemoattractant for monocytes, T cells, and natural killer cells.
Activation of protein kinase C dramatically increases the rate of this cleavage. Regulation of
FK cleavage is critical for maintaining the balance between the immobilized and soluble …
endothelial cells. As a full-length transmembrane protein, FK binds cells expressing
CX3CR1, its cognate receptor, with high affinity. Proteolytic cleavage of FK releases a
soluble form that is a potent chemoattractant for monocytes, T cells, and natural killer cells.
Activation of protein kinase C dramatically increases the rate of this cleavage. Regulation of
FK cleavage is critical for maintaining the balance between the immobilized and soluble …