The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
LL Lanier, ABH Bakker - Immunology today, 2000 - cell.com
LL Lanier, ABH Bakker
Immunology today, 2000•cell.comDAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with
receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk
and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12
(DAP12−/−) show normal development of hematopoietic cells. However, DAP12−/− humans
develop presenile dementia and bone cysts, and DAP12−/− mice show impaired immune
responses.
receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk
and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12
(DAP12−/−) show normal development of hematopoietic cells. However, DAP12−/− humans
develop presenile dementia and bone cysts, and DAP12−/− mice show impaired immune
responses.
Abstract
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12−/−) show normal development of hematopoietic cells. However, DAP12−/− humans develop presenile dementia and bone cysts, and DAP12−/− mice show impaired immune responses.
cell.com