[HTML][HTML] Membrane-bound α-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form
α-Synuclein exists as at least two structural isoforms: a helix-rich, membrane-bound form
and a disordered, cytosolic form. Here, we investigated the role of membrane-bound α-
synuclein in the aggregation process. In a cell-free system consisting of isolated brain
fractions, spontaneous and progressive aggregation of α-synuclein was observed in
membranes starting at day 1, whereas no aggregation was observed in the cytosolic fraction
in a 3-day period. The addition of antioxidants reduced the aggregation in the membrane …
and a disordered, cytosolic form. Here, we investigated the role of membrane-bound α-
synuclein in the aggregation process. In a cell-free system consisting of isolated brain
fractions, spontaneous and progressive aggregation of α-synuclein was observed in
membranes starting at day 1, whereas no aggregation was observed in the cytosolic fraction
in a 3-day period. The addition of antioxidants reduced the aggregation in the membrane …