Constitutive phosphorylation of the Parkinson's disease associated α-synuclein
M Okochi, J Walter, A Koyama, S Nakajo… - Journal of Biological …, 2000 - ASBMB
α-Synuclein has been implicated in the pathogenesis of Parkinson's disease, since rare
autosomal dominant mutations are associated with early onset of the disease and α-
synuclein was found to be a major constituent of Lewy bodies. We have analyzed α-
synuclein expression in transfected cell lines. In pulse-chase experiments α-synuclein
appeared to be stable over long periods (t 1 2 54 h) and no endoproteolytic processing was
observed. α-Synuclein was constitutively phosphorylated in human kidney 293 cells as well …
autosomal dominant mutations are associated with early onset of the disease and α-
synuclein was found to be a major constituent of Lewy bodies. We have analyzed α-
synuclein expression in transfected cell lines. In pulse-chase experiments α-synuclein
appeared to be stable over long periods (t 1 2 54 h) and no endoproteolytic processing was
observed. α-Synuclein was constitutively phosphorylated in human kidney 293 cells as well …