Sister cytotoxic CD8+ T cell clones differing in natural killer inhibitory receptor expression in human astrocytoma
G Perrin, D Speiser, A Porret, AL Quiquerez… - Immunology letters, 2002 - Elsevier
Natural killer (NK) inhibitory receptors are thought to play a critical role in the regulation of
cytotoxicity of NK cells and certain self-reactive T cells. In the present study, we investigated
whether astrocytoma infiltrating T lymphocytes may be functionally compromised by NK
receptors (NKRs). The NK inhibitory receptor CD94/NKG2A was found on a significant
proportion of CD8+ astrocytoma infiltrating lymphocytes. The functional consequences of
CD94/NKG2A expression were explored at the clonal level, using a T cell clone that …
cytotoxicity of NK cells and certain self-reactive T cells. In the present study, we investigated
whether astrocytoma infiltrating T lymphocytes may be functionally compromised by NK
receptors (NKRs). The NK inhibitory receptor CD94/NKG2A was found on a significant
proportion of CD8+ astrocytoma infiltrating lymphocytes. The functional consequences of
CD94/NKG2A expression were explored at the clonal level, using a T cell clone that …
