[HTML][HTML] Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells
Adenosine exerts a mitogenic effect on human endothelial cells via stimulation of the A 2A-
adenosine receptor. This effect can also be elicited by the β 2-adrenergic receptor but is not
mimicked by elevation of intracellular cAMP levels. In the present work, we report that
stimulation of the A 2A-adenosine receptor and of the β 2-adrenergic receptor activates
mitogen-activated protein kinase (MAP kinase) in human endothelial cells based on the
following criteria: adenosine analogues and β-adrenergic agonists cause an (i) increase in …
adenosine receptor. This effect can also be elicited by the β 2-adrenergic receptor but is not
mimicked by elevation of intracellular cAMP levels. In the present work, we report that
stimulation of the A 2A-adenosine receptor and of the β 2-adrenergic receptor activates
mitogen-activated protein kinase (MAP kinase) in human endothelial cells based on the
following criteria: adenosine analogues and β-adrenergic agonists cause an (i) increase in …