Characterization of the adenosine receptor in microvascular coronary endothelial cells
JO Schiele, U Schwabe - European Journal of Pharmacology: Molecular …, 1994 - Elsevier
In the present work we studied the effect of adenosine and various analogues on cAMP level
in guinea pig coronary endothelial cells of microvascular origin. The tested adenosine
agonists mediate a concentration-dependent increase in cAMP level. The rank order of
potency was 5′-N-ethylcarboxamidoadenosine (NECA)> CGS 21680> N 6-
phenylisopropyladenosine (R-PIA)> 2-chloro-N 6-cyclopentyladenosine (CCPA) which is
typical for an adenosine A 2 receptor. Their respective concentrations for half maximal …
in guinea pig coronary endothelial cells of microvascular origin. The tested adenosine
agonists mediate a concentration-dependent increase in cAMP level. The rank order of
potency was 5′-N-ethylcarboxamidoadenosine (NECA)> CGS 21680> N 6-
phenylisopropyladenosine (R-PIA)> 2-chloro-N 6-cyclopentyladenosine (CCPA) which is
typical for an adenosine A 2 receptor. Their respective concentrations for half maximal …