Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.
K Ueda, I Pastan, MM Gottesman - Journal of Biological Chemistry, 1987 - ASBMB
Intrinsic and acquired multidrug resistance is an important problem in cancer therapy.
Multidrug resistance results from overexpression of the MDR 1 gene, which encodes a drug-
efflux pump called P-glycoprotein. We have isolated a 1-kilobase genomic fragment
containing the major transcription initiation sites for the human MDR 1 gene. Ribonuclease
protection experiments using this fragment indicate that normal human adrenal, colon, and
liver cells, the human hepatoma cell line HepG2, and vinblastine-selected human KB …
Multidrug resistance results from overexpression of the MDR 1 gene, which encodes a drug-
efflux pump called P-glycoprotein. We have isolated a 1-kilobase genomic fragment
containing the major transcription initiation sites for the human MDR 1 gene. Ribonuclease
protection experiments using this fragment indicate that normal human adrenal, colon, and
liver cells, the human hepatoma cell line HepG2, and vinblastine-selected human KB …