Transcriptional regulation of Th1/Th2 polarization
J Rengarajan, SJ Szabo, LH Glimcher - Immunology today, 2000 - cell.com
J Rengarajan, SJ Szabo, LH Glimcher
Immunology today, 2000•cell.comThe two polarized T helper (Th) subsets Th1 and Th2 are identified by their signature
cytokines, interferon γ (IFN-γ) and interleukin 4 (IL-4) respectively. Understanding the
transcriptional regulation of cytokine expression is therefore critical for elucidating the
process of Th cell differentiation. Ubiquitous and tissue-specific transcription factors, as well
as chromatin remodeling of genomic loci have been implicated in IL-4 and IFN-γ regulation.
We propose a model of Th1/Th2 polarization based on the balance between Th1-and Th2 …
cytokines, interferon γ (IFN-γ) and interleukin 4 (IL-4) respectively. Understanding the
transcriptional regulation of cytokine expression is therefore critical for elucidating the
process of Th cell differentiation. Ubiquitous and tissue-specific transcription factors, as well
as chromatin remodeling of genomic loci have been implicated in IL-4 and IFN-γ regulation.
We propose a model of Th1/Th2 polarization based on the balance between Th1-and Th2 …
Abstract
The two polarized T helper (Th) subsets Th1 and Th2 are identified by their signature cytokines, interferon γ (IFN-γ) and interleukin 4 (IL-4) respectively. Understanding the transcriptional regulation of cytokine expression is therefore critical for elucidating the process of Th cell differentiation. Ubiquitous and tissue-specific transcription factors, as well as chromatin remodeling of genomic loci have been implicated in IL-4 and IFN-γ regulation. We propose a model of Th1/Th2 polarization based on the balance between Th1- and Th2-specific transcription factors.
cell.com
