Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium
RE Mullings, SJ Wilson, SM Puddicombe… - Journal of Allergy and …, 2001 - Elsevier
Background: Asthma is associated with increased production of IL-4 and IL-13. Objective:
Because many of the effects of these cytokines are mediated by activation of signal
transducer and activator of transcription 6 (STAT-6), we investigated expression and function
of this transcription factor in the airways. Methods: STAT-6 expression was investigated
through use of immunohistochemistry or RT-PCR applied to bronchial biopsy specimens or
brushings from normal control or asthmatic subjects. STAT-6 function was investigated by …
Because many of the effects of these cytokines are mediated by activation of signal
transducer and activator of transcription 6 (STAT-6), we investigated expression and function
of this transcription factor in the airways. Methods: STAT-6 expression was investigated
through use of immunohistochemistry or RT-PCR applied to bronchial biopsy specimens or
brushings from normal control or asthmatic subjects. STAT-6 function was investigated by …
