[HTML][HTML] Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons∗
JA Borkowski, RW Ransom, GR Seabrook… - Journal of Biological …, 1995 - ASBMB
Mice that are homozygous for the targeted disruption of the gene encoding the B 2
bradykinin receptor have been generated. The gene disruption results in a deletion of the
entire coding sequence for the B 2 receptor. The disruption of the B 2 receptor gene has
been confirmed by genetic, biochemical, and pharmacological analyses. Mice that are
homozygous for the disruption of the B 2 receptor gene are fertile and indistinguishable from
their littermates by visual inspection. Bradykinin fails to produce responses in …
bradykinin receptor have been generated. The gene disruption results in a deletion of the
entire coding sequence for the B 2 receptor. The disruption of the B 2 receptor gene has
been confirmed by genetic, biochemical, and pharmacological analyses. Mice that are
homozygous for the disruption of the B 2 receptor gene are fertile and indistinguishable from
their littermates by visual inspection. Bradykinin fails to produce responses in …