Effect of bradykinin and thrombin on prostacyclin synthesis in endothelial cells from calf and pig aorta and human umbilical cord vein
SL Hong - Thrombosis research, 1980 - Elsevier
We have discovered that bradykinin is effective in causing the synthesis of prostacyclin in
endothelial cells cultured from calf and pig aorta and human umbilical cord vein. Maximal
stimulation is attained at 10 ng bradykinin per ml with a 10 fold increase of PGI 2 as assayed
by radioimmunoassay for 6-k-PGF 1α. Ionophore A23187, trypsin, and the precursor
arachidonic acid are also stimulatory. We have confirmed the study of Weksler et al (J. Clin.
Invest., 62, 923, 1978) and Czervionke et al (Thrombosis Research, 14, 781, 1979) that …
endothelial cells cultured from calf and pig aorta and human umbilical cord vein. Maximal
stimulation is attained at 10 ng bradykinin per ml with a 10 fold increase of PGI 2 as assayed
by radioimmunoassay for 6-k-PGF 1α. Ionophore A23187, trypsin, and the precursor
arachidonic acid are also stimulatory. We have confirmed the study of Weksler et al (J. Clin.
Invest., 62, 923, 1978) and Czervionke et al (Thrombosis Research, 14, 781, 1979) that …
