[HTML][HTML] Lysosomal integral membrane protein II binds thrombospondin-1: structure-function homology with the cell adhesion molecule CD36 defines a conserved …
R Crombie, R Silverstein - Journal of Biological Chemistry, 1998 - ASBMB
LIMPII (lysosomalintegral membrane protein II) is one of a family of proteins structurally
related to the cell surface glycoprotein CD36. We recently defined a single structural domain
on CD36 that mediates binding to adhesive glycoprotein thrombospondin-1 (TSP1). The
CD36-TSP1 interaction is known to play a role in platelet-tumor and platelet-monocyte
adhesion, angiogenesis, and in monocyte uptake of apoptotic cells. To test whether LIMPII
also binds TSP1, a LIMPII peptide corresponding to the TSP1 binding domain of CD36 was …
related to the cell surface glycoprotein CD36. We recently defined a single structural domain
on CD36 that mediates binding to adhesive glycoprotein thrombospondin-1 (TSP1). The
CD36-TSP1 interaction is known to play a role in platelet-tumor and platelet-monocyte
adhesion, angiogenesis, and in monocyte uptake of apoptotic cells. To test whether LIMPII
also binds TSP1, a LIMPII peptide corresponding to the TSP1 binding domain of CD36 was …
